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CHIMICA DEI COMPOSTI ETEROCICLICI FARMACOLOGICAMENTE ATTIVI PDF

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Emivita, 2 ore Molecola madre; 9 ore MHD metabolita attivo principale. Escrezione, Urinaria (l’1% in forma immodificata). Indicazioni di sicurezza. Frasi H, Consigli P, Modifica dati su Wikidata · Manuale. L’oxcarbazepina o oxcarbamazepina è un farmaco chimicamente correlato alla . Le concentrazioni plasmatiche del metabolita attivo di oxcarbazepina. Università degli studi di Parma. via Università, 12 – I Parma. tel. + email: [email protected] · [email protected] composti farmacologicamente attivi. Recentemente ed efficiente, ha permesso la preparazione di nuovi inibitori eterociclici non peptidici, aventi anelli tienilici.

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HETEROCYCLIC PHARMACEUTICAL CHEMISTRY | Università degli Studi di Sassari

Therefore the aim of this course is the study of main heterocyclic rings monocyclic, bicyclic and polycyclic as basic components of pharmacologically active compounds.

This study includes the nomenclature, reactivity and synthesis of such compounds.

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Electron-rich heteroaromatic rings reactivity pyrrole, furan, thiophene and indol. Paal-Knorr, Knorr and Hantzsch synthesis of pyrrolic ring; Paal-Knorr and Feist-Benary synthesis of furanic ring; Paal synthesis of thiophenic ring; Fischer and Reissert synthesis of indolic ring.

Pentatomic heterocycles containing two heteroatoms: Imidazole, oxazole e thiazole: Comparison between pyrrole eteroxiclici pyridine reactivity and application of analogies and differences with 1,2 and 1,3-azoles.

Imidazolic, oxazolic and thiazolic rings synthesis. Pyrazole, isoxazole and thiazole.

Electron-poor heteroaromatic rings reactivity pyridine, quinoline and isoquinoline. Use of N-oxides derivatives in of electrophylic aromatic substitution reactions.

Alkyl derivatives reactivity of pyridine and derivatives.

Synthesis from 1,5-diketones, followed by oxidation, and Hantzsch’s synthesis of pyridinic ring. Skraup synthesis of quinoline and Biskler-Napieralsky synthesis of isoquinoline.

Pinner synthesis of pyrimidine. Synthesis of barbituric acid. Availability to offer individual assistance in English language to incoming students.

Availability of supporting material and bibliographic references in English language. Availability to accept examination of incoming students in English Language written examination.

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Primidone – Wikipedia

Skip to main content. Single discipline educational activity. Academic Year of enrolment: Hours of classroom activity: Lectures with slides’ support.